Browsing by Author "Coskun, Kubra Acikalin"
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Design and synthesis of pyrimidinyl acyl thioureas as novel Hsp90 inhibitors in invasive ductal breast cancer and its bone metastasis
Koca, Irfan; Ozgur, Aykut; Er, Muhammet; Gumus, Mehmet; Coskun, Kubra Acikalin; Tutar, Yusuf (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2016)Invasive ductal carcinoma is the most common breast malignancies tumors and has tendency to bone metastases. Many oncogenic client proteins involved in formation of metastatic pathways. Stabilization, regulation, and ... -
Determination of Optimum Operation Parameters for Low-Intensity Pulsed Ultrasound and Low-Level Laser Based Treatment to Induce Proliferation of Osteoblast and Fibroblast Cells
Coskun, Mehmet Emre; Coskun, Kubra Acikalin; Tutar, Yusuf (MARY ANN LIEBERT, INC, 2018)Objective: The aim of this study was to determine the optimum operating parameters (pulse duration, energy levels, and application time) to promote induction of osteoblast and fibroblast cell proliferation and to maintain ... -
Isolation and characterization of Heat Shock Protein 100-Batu1 from Toxoplasma gondii RH strain
Coskun, Kubra Acikalin; Tutar, Yusuf (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2015)Toxoplasma gondii is an intracellular parasitic protozoon which infects human and most warm-blooded animals. Almost one-third of the world's population is affected by life-threatening infection of T. gondii tachyzoites ... -
Isolation and Identification of Free-Living Amoebae from Tap Water in Sivas, Turkey
Coskun, Kubra Acikalin; Ozcelik, Semra; Tutar, Lutfi; Elaldi, Nazif; Tutar, Yusuf (HINDAWI PUBLISHING CORPORATION, 2013)The present work focuses on a local survey of free-living amoebae (FLA) that cause opportunistic and nonopportunistic infections in humans. Determining the prevalence of FLA in water sources can shine a light on the need ... -
Synthesis and anticancer activity of acyl thioureas bearing pyrazole moiety
Koca, Irfan; Ozgur, Aykut; Coskun, Kubra Acikalin; Tutar, Yusuf (PERGAMON-ELSEVIER SCIENCE LTD, 2013)In this work novel organic based compounds, acyl thiourea derivatives were synthesized and their anticancer activities were investigated. A new series of acyl thiourea derivatives containing pyrazole ring were prepared in ...